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. 2023 Aug 3;12:e79548. doi: 10.7554/eLife.79548

Appendix 2—table 44. Antidepressant User Cohort (All Regions) by BP Use, Patient Characteristics Pre/Post Match of BP Users/Non-users.

All Antidepressant Users by BP: Unmatched All Antidepressant Users by BP: Matched
All BP Non-user BP User p-value All BP Non-user BP User p-value
N % N % N % N % N % N %
All Patients 1,536,048 100.0% 1,390,939 90.6% 145,109 9.4% 288,564 100.0% 144,282 50.0% 144,282 50.0%
Age
≤20 89,571 5.8% 89,415 6.4% 156 0.1% <0.001 313 0.1% 157 0.1% 156 0.1% 1.00
21-40 315,593 20.5% 314,429 22.6% 1,164 0.8% 2,326 0.8% 1,162 0.8% 1,164 0.8%
41-50 233,345 15.2% 229,878 16.5% 3,467 2.4% 6,933 2.4% 3,467 2.4% 3,466 2.4%
51-60 333,655 21.7% 310,316 22.3% 23,339 16.1% 46,674 16.2% 23,339 16.2% 23,335 16.2%
61-70 296,163 19.3% 244,247 17.6% 51,916 35.8% 103,798 36.0% 51,905 36.0% 51,893 36.0%
71-80 169,299 11.0% 126,089 9.1% 43,210 29.8% 85,292 29.6% 42,643 29.6% 42,649 29.6%
≥81 98,422 6.4% 76,565 5.5% 21,857 15.1% 43,228 15.0% 21,609 15.0% 21,619 15.0%
Gender
Female 1,109,599 72.2% 976,214 70.2% 133,385 91.9% <0.001 265,123 91.9% 132,553 91.9% 132,570 91.9% 0.91
Male 426,449 27.8% 414,725 29.8% 11,724 8.1% 23,441 8.1% 11,729 8.1% 11,712 8.1%
Region
Midwest 335,508 21.8% 309,597 22.3% 25,911 17.9% <0.001 51,754 17.9% 25,877 17.9% 25,877 17.9% 1.00
Northeast 383,023 24.9% 347,944 25.0% 35,079 24.2% 70,010 24.3% 35,005 24.3% 35,005 24.3%
South 596,029 38.8% 540,382 38.9% 55,647 38.3% 110,518 38.3% 55,259 38.3% 55,259 38.3%
West 221,488 14.4% 193,016 13.9% 28,472 19.6% 56,282 19.5% 28,141 19.5% 28,141 19.5%
Insurance
Commercial 707,676 46.1% 664,625 47.8% 43,051 29.7% <0.001 86,053 29.8% 43,023 29.8% 43,030 29.8% 1.00
Dual 54,840 3.6% 43,171 3.1% 11,669 8.0% 22,384 7.8% 11,193 7.8% 11,191 7.8%
Medicaid 486,451 31.7% 457,656 32.9% 28,795 19.8% 56,959 19.7% 28,479 19.7% 28,480 19.7%
Medicare 287,081 18.7% 225,487 16.2% 61,594 42.4% 123,168 42.7% 61,587 42.7% 61,581 42.7%
PCP Visit 2019
No 605,264 39.4% 553,886 39.8% 51,378 35.4% <0.001 102,148 35.4% 51,064 35.4% 51,084 35.4% 0.94
Yes 930,784 60.6% 837,053 60.2% 93,731 64.6% 186,416 64.6% 93,218 64.6% 93,198 64.6%
Continuous Outcomes
mean SD mean SD mean SD p-value mean SD mean SD mean SD p-value
CCI 0.87 1.60 0.84 1.58 1.09 1.81 <0.001 1.09 1.79 1.08 1.78 1.09 1.79 0.56

BP: bisphosphonate; CCI: Charlson Comorbidity Index; PCP: primary care physician; SD: standard deviation.