Table 2.
The log Po/w, log D, and pKa values of compounds 1-6.
Compound | log Po/w | pKa | log D | ||
---|---|---|---|---|---|
pH 7.4 | pH 7.2 | pH 5.5 | |||
1 | 2.21 | 9.04 10.40 |
3.39 | 3.39 | 3.40 |
| |||||
2 | 1.34 | 8.82 10.96 14.49 |
2.61 | 2.61 | 2.62 |
| |||||
3 | 1.61 | 8.78 10.90 14.46 |
2.93 | 2.93 | 2.94 |
| |||||
4 | 1.92 | 8.82 10.96 14.49 |
3.10 | 3.10 | 3.11 |
| |||||
5 | 2.63 | 8.32 | 3.60 | 3.62 | 3.65 |
| |||||
6 | 2.97 | 8.35 | 3.78 | 3.79 | 3.82 |
| |||||
CA | 0.93 | 3.45 9.28 12.69 |
-1.67 | -1.58 | -0.21 |
| |||||
CQ | 4.15 | 7.29 10.32 |
0.70 | 0.44 | -1.21 |