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. 2023 Mar 21;62(12):3875–3885. doi: 10.1093/rheumatology/kead135

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© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Association of knee osteoarthritis inflammatory phenotypes (KOIP) with clinical severity and radiographic progression. Panels (A) and (B) represent boxplots showing the distribution of knee injury and osteoarthritis outcome scores (KOOS, reversed scores) across KOIP groups for pain (A) and functional disability (B). Panels (C), (D) and (E) display the percentage of patients whose disease progressed after a two-year follow-up according to different radiographic criteria, namely Kellgren–Lawrence (KL) stage (C), formation of new osteophytes (D) and increase of joint space narrowing (JSN) (E). Diamond-shaped points and segments show group medians (A and B), percentages (C, D and E) and their 95% CI. P-values are derived from an Kruskal–Wallis test (A, B) or a Fisher’s test for contingency tables (C, D and E). KOIP: knee osteoarthritis inflammatory phenotype; KOOS: knee injury and osteoarthritis outcome scores (reversed scores)