Table 5.
CAG and OCT findings for different LDL-C levels
| Overall (n = 216) |
LDL-C < 2.51 mmol/L (n = 123) |
LDL-C ≥ 2.51 mmol/L (n = 93) | p value | |||
|---|---|---|---|---|---|---|
| CAG finding | ||||||
| Lesion length, mm | 12.05 (8.80-17.15) | 11.50 (8.60–16.70) | 12.60 (8.85–17.85) | 0.154 | ||
| Multivessel disease | 170 (78.7) | 91 (74.0) | 79 (84.9) | 0.051 | ||
| Reference vessel diameter, mm | 3.19 ± 0.41 | 3.19 ± 0.41 | 3.19 ± 0.41 | 0.924 | ||
| MLD, mm | 1.16 ± 0.22 | 1.16 ± 0.21 | 1.15 ± 0.24 | 0.945 | ||
| Diameter stenosis, % | 63.63 ± 6.00 | 63.53 ± 5.73 | 63.76 ± 6.37 | 0.784 | ||
| ISR location | 0.922 | |||||
| LAD | 133 (61.6) | 75 (61.0) | 58 (62.4) | |||
| LCX | 23 (10.6) | 14 (11.4) | 9 (9.7) | |||
| RCA | 60 (27.8) | 34 (27.6) | 26 (28.0) | |||
| ISR pattern | 0.395 | |||||
| Focal | 86 (39.8) | 52 (42.3) | 34 (36.6) | |||
| Diffuse | 130 (60.2) | 71 (57.7) | 59 (63.4) | |||
| Previous stent type | ||||||
| First-generation DES | 159 (73.6) | 88 (71.5) | 71 (76.3) | 0.889 | ||
| New-generation DES | 46 (21.3) | 29 (23.6) | 17 (18.3) | |||
| Unknown | 11 (5.1) | 6 (4.9) | 5 (5.4) | |||
| OCT finding | ||||||
| Quantitative analysis | ||||||
| MLA, mm2 | 1.68 ± 0.58 | 1.72 ± 0.57 | 1.62 ± 0.60 | 0.223 | ||
| Stent area (MLA site), mm2 | 6.58 ± 1.62 | 6.70 ± 1.68 | 6.43 ± 1.55 | 0.236 | ||
|
Neointimal tissue area (MLA site), mm 2 |
4.90 ± 1.47 | 4.97 ± 1.52 | 4.81 ± 1.40 | 0.408 | ||
| Burden of neointimal tissue (MLA site), % | 73.81 ± 8.73 | 73.53 ± 8.26 | 74.17 ± 9.36 | 0.594 | ||
| Qualitative analysis | ||||||
| NA | 117 (54.2) | 52 (42.3) | 65 (69.9) | < 0.001 | ||
| TCFA | 42 (19.4) | 17 (13.8) | 25 (26.9) | 0.016 | ||
| Intimal rupture | 40 (18.5) | 16 (13.0) | 24 (25.8) | 0.017 | ||
| Plaque erosion | 60 (27.8) | 27 (22.0) | 33 (35.5) | 0.028 | ||
| Macrophage | 42 (19.4) | 22 (17.9) | 20 (21.5) | 0.506 | ||
| NV | 96 (44.4) | 54 (43.9) | 42 (45.2) | 0.854 | ||
| Thrombus | 54 (25.0) | 24 (19.8) | 30 (32.3) | 0.038 | ||
Data are expressed as the median (interquartile range), mean ± SD, or n (%). CAG: coronary angiography; DES: drug eluting stent; ISR: in-stent restenosis; LAD: left anterior descending artery; LCX: left circumflex artery; LDL-C: low-density lipoprotein cholesterol; MLA: minimum lumen area; MLD: minimal lumen diameter; NA: neoatherosclerosis; NV: neovascularization; OCT: optical coherence tomography; RCA: right coronary artery; TCFA: thin-cap fibroatheroma