Table 6.
Summary for the steroid receptor IHC staining data for the POP and control USL phenotypes
| Control | POP-A(dipose) | POP-I(nflammatory) | POP-V(ascular) | ||
|---|---|---|---|---|---|
| N | 15 | 8 | 9 | 11 | |
| Receptor | Cell type | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD |
| ER alpha | Smooth muscle | 43.3 ± 13.9 | 58.4 ± 4.3 | 53.8 ± 10.2 | 55.5 ± 17.5 |
| Connective tissue | 19.9 ± 11.7a | 20.1 ± 5.8 | 17.0 ± 6.5b | 33.1 ± 14.9ab | |
| ER beta | Smooth muscle | 55.4 ± 3.6 | 55.5 ± 4.8 | 50.8 ± 5.0 | 51.6 ± 4.5 |
| Arterial smooth muscle | 56.3 ± 4.6 | 62.0 ± 7.8 | 57.7 ± 4.9 | 62.9 ± 8.3 | |
| Endothelial cells | 68.7 ± 4.7 | 65.8 ± 8.0 | 70.3 ± 3.3a | 63.4 ± 6.0a | |
| Connective tissue | 34.5 ± 4.2a | 38.1 ± 3.1 | 38.7 ± 6.2 | 40.7 ± 6.7a | |
| GPER | Smooth muscle | 54.7 ± 5.6a | 54.9 ± 4.5b | 60.4 ± 6.3 | 66.4 ± 8.9ab |
| Arterial smooth muscle | 64.0 ± 5.7 | 62.1 ± 3.6 | 62.0 ± 3.3 | 67.9 ± 8.0 | |
| Endothelial cells | 73.9 ± 6.9a | 66.0 ± 5.1a* | 74.1 ± 6.2a | 78.0 ± 5.9a | |
| Connective tissue | 63.8 ± 5.5a | 66.4 ± 5.0a | 63.6 ± 4.2a | 74.7 ± 8.5a* | |
| AR | Smooth muscle | 35.7 ± 7.3 | 36.5 ± 8.5 | 36.8 ± 9.3 | 42.8 ± 10.0 |
| Connective tissue | 17.4 ± 4.1a | 18.1 ± 3.7b | 25.8 ± 9.5 | 34.0 ± 11.3ab |
Average and standard deviations of the mean are included for the results of each steroid receptor IHC for each phenotype of subjects. The N of each group is indicated. Statistical comparisons of the steroid receptor IHC data for all phenotypes of subjects were performed using R software with required packages indicated where appropriate [29]. Welch’s unequal variances t-test was used when the phenotypes had unequal variances and were of unequal sample size. Analysis of variance with Tukey’s post hoc pairwise test was used when making multiple comparisons between continuous variables and Pearson’s Chi-squared test with Yates’ continuity correction for categorical variables (R package “RVAideMemoire”). Mean values that significantly differ from one another are denoted by letters (a, b); p < 0.05 as determined by ANOVA followed by Tukey’s post hoc pairwise test. (*) indicate significance where p<0.05 between indicated group and all other groups.