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. 2023 Jul 14;30(12):3410–3427. doi: 10.1007/s43032-023-01287-9

Table 3.

Overview of genome-wide association studies (GWAS) published between 2011 and 2023 with genome-wide significant results (P<5×10−08)

Study Genes identified Sample Total sample size Ethnicities analyzed Phenotypes analyzed
Solé-Navais, 2023 [127] ADCY5; AGTR2; COL27A1; EBF1; EEFSEC; FAF1; FBXO32; GDAP1; HAND2; HIVEP3; HLA-DQA1; KCNAB1; KDR; LEKR1; LRP5; LSM3; MRPS22; MYOCD; RAP2C; TCEA2; TET3; TFAP4; WNT4; ZBTB38 Maternal 279043 European sPTB <37 weeks, Gestational duration
Gupta, 2022 [130] LOC105377408; MAST1 Maternal 310 European Preterm prelabor rupture of membranes (PPROM) <34 weeks; spontaneous preterm birth (sPTB) <34 weeks
Huusko, 2021 [139] DNAJB8 Maternal 43568 European sPTB <37 weeks
Liu, 2019 [131] CKAP2L; IL1A; IL1B; NT5DC4 Infant 84689 European sPTB <34 weeks, Gestational duration
Rappoport, 2018 [132] YWHAQP9/RP11-136B18; FAM87A/FBXO25 Infant 1847 African; American sPTB <30wks
Zhang, 2017 [129] EBF1; EEFSEC; RUVBL1; TEKT3/PMP22/TVP23C-CDRT4; AGTR2/PLS3; WNT4; ADCY5; TET3; RAP2C/FRMD7/STK26 Maternal 43567 European sPTB <37 weeks; Gestational duration