Table 4.
Effect of the different treatments on the joint score
| Synovial proliferation | Inflammation | Degenerative changes | Total (out of 9) | |
|---|---|---|---|---|
| NC | 0 | 0 | 0 | 0 |
| AA | 3 | 3 | 2 | 8* |
| MTX | 2 | 2 | 2 | 6* |
| RH | 2 | 2 | 1 | 5 |
| RH-MTX | 2 | 2 | 1 | 5 |
| MTX-SLN | 0 | 1 | 1 | 2# |
| RH-SLN | 1 | 1 | 1 | 3# |
| RH-MTX-SLN | 0 | 1 | 0 | 1# |
Three fields per each joint were assessed and data presented as mean, n = 4. The grades were then summed up into a total score out of 9. Symbols show a comparison to * negative control (NC), and # positive control (AA), using Kruskal–Wallis Test (p < 0.05). MTX: methotrexate solution, RH: rhein solution, RH-SLNs: rhein loaded on solid lipid nanoparticles, MTX-SLNs: methotrexate loaded on solid lipid nanoparticles, RH-MTX-SLNs: combination of methotrexate and rhein loaded on solid lipid nanoparticles