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. 2023 Aug 18;44(12):2455–2468. doi: 10.1038/s41401-023-01140-4

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© The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 2 — a Schematic representation of the production and harvest of engineered Exos encapsulating the cluster 3 with RVG peptide. Image was drew using BioRender.com. b Morphology of RVG-Exos under TEM. Scale bars, 100 nm. c Representative NTA validation of the size distribution of RVG-Exos. d Western blot analysis of exosomal marker proteins (Alix, CD63, and CD81). e qRT‒PCR analysis of miR-23a-3p, miR-26a-5p and miR-27a-3p expression in the db/db mice treated with RVG-miR-23a/27a/26a-Exos. The results are normalized to U6. f Imaging of fluorescence intensity in the db/db mice after intravenous injection of RVG-miR-23a/27a/26a-Exos or miR-23a/27a/26a-Exos. g qPCR analysis of miR-23a-3p, miR-26a-5p and miR-27a-3p expression in the kidney after intravenous injection of RVG-miR-23a/27a/26a-Exos and miR-23a/27a/26a-Exos. **P < 0.01, ***P < 0.001. Exo, exosome; RVG, rabies virus glycoprotein.