Skip to main content
. 2023 Aug 18;44(12):2455–2468. doi: 10.1038/s41401-023-01140-4

Fig. 4. RVG-miR-23a/27a/26a-Exos inhibit ECM accumulation in HG-treated TECs.

Fig. 4

(a) Representative fluorescent images show the uptake of DiD-labeled RVG-miR-23a/27a/26a-Exos by HG-treated TECs. Scale bars, 10 µm. (b) The expression of miR-23a-3p, miR-26a-5p and miR-27a-3p in the HG-treated TECs treated with RVG-miR-23a/27a/26a-Exos. The relative levels were normalized to U6. (c, d) Western blot and qRT‒PCR analyses of α-SMA, collagen-1, Fibronectin, and E-cadherin expression. The relative levels were normalized to GAPDH. (e) Representative images of α-SMA immunostaining. Scale bars, 10 μm. **P < 0.01, ***P < 0.001. HG, high glucose.