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. 2023 Aug 18;44(12):2455–2468. doi: 10.1038/s41401-023-01140-4

Fig. 5. Synergistic antifibrotic activity of RVG-miR-23a/27a/26a-Exos in mice with DN.

Fig. 5

a Effects of RVG-miR-23a/27a/26a-Exos, RVG-miR-23a/27a-Exos and RVG-miR-26a-Exos on sCr and 24 h urinary protein of the mice with DN. b Representative images of PAS and Masson staining of the renal cortex. Scale bars, 20 μm. c, d Quantification of tubular injury and TIF based on PAS and Masson staining. n = 7 per group. e Representative images of α-SMA and Kim-1 immunostaining. Scale bars, 20 μm (α-SMA). Scale bars, 50 μm (Kim-1). f, g qRT‒PCR and Western blot analyses of α-SMA, collagen-1, and Kim-1 expression. The relative levels were normalized to GAPDH. *P < 0.05, **P < 0.01, ***P < 0.001.