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. 2023 Dec 2;13:21259. doi: 10.1038/s41598-023-48094-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Co-expression analysis in ACD patients. (A) Correlation values heatmap obtained from WGCNA module analysis of co-expressed genes in ACD patients. Upper value corresponds to the individual correlation value of the module with musical stimuli. P-values of these correlations are shown in brackets (B) Raincloud plots of differences in individual samples eigengenes between TP1 and TP2 from modules showing the largest statistical significance in ACD patients. (C) Top biological processes detected from most statistically significant modules. Modules with significant pathways are named as the hub gene names CMTM6 and TPM3. (D) Module membership (MM) and phenotype correlation (musical stimuli) for genes from the most significant pathways obtained from the modules CMTM6 and TPM3.