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. 2023 Dec 2;13:21259. doi: 10.1038/s41598-023-48094-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation patterns of genes between the comparisons ‘ACD patients in TP1 versus TP2’ to (i) ‘MCI versus healthy controls’, and (ii) ‘AD versus healthy controls’. (A) Dots indicate log₂FC values for genes shared between the comparisons; blue dots are DEGs with significant FDR < 0.05. (B) FDR DEGs_MCI; (C) FDR DEGs_AD. For (B) and (C): only top DEG names are displayed (yellow points); these top elements were identified by first selecting the best 50 FDR values and top 50 higher |log₂FC| from each comparison separately; next selecting the shared elements between the two comparisons. For the top DEGs we also show boxplots of (normalized) expression. Spearman correlation values and the number of genes plotted in each quadrant are indicated. For all the correlation values, P-value < 2.2 × 10^–16. MCI Mild cognitive impairment; AD Alzheimer’s disease; HC Healthy controls; ACD Age-related cognitive disorder.