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. 2023 Aug 7;44(12):2358–2375. doi: 10.1038/s41401-023-01123-5

Fig. 3. Role of TLRs in the formation of AS.

Fig. 3

CD80 cluster of differentiation 80, CD86 cluster of differentiation 86, CCL5 RANTES, CD40L CD40 Ligand, CXCL4 C-X-C motif chemokine 4/ Platelet factor 4, ERK1/2 extracellular regulated protein kinases 1/2, ICAM-1 intercellular cell adhesion molecule-1, IL-1 interleukin-1, IL-6 interleukin-6, IL-8 interleukin-8, IL-12 interleukin-12, IP-10 IFN-γ inducible protein-10, MAFB The bZip transcription factor, MCP-1 monocyte chemoattractant protein 1, MMP2 matrix metalloproteinase-2, MMP9 matrix metalloproteinase-9, NF-κB nuclear factor κB, PI3K/AKT Phosphatidylinositide 3-kinases/protein kinase B, ROS reactive oxygen species, TN-C Tenascin-C, TREMs Triggering receptors expressed on myeloid cells, VCAM-1 vascular cell adhesion molecule-1.