Table 4.
Association of anthropometric or MetS variables and all-cause or BC-specific mortality by luminal subtypes (A vs. B).
| Variable | Luminal A | Luminal B | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Deaths/N total cases | Deaths from all-causes | Deaths from breast cancer | Deaths/N total cases | Deaths from all-causes | Deaths from breast cancer | |||||
| HR* (95% CI) | p** | HR (95% CI) | p** | HR* (95% CI) | p** | HR (95% CI) | p** | |||
| Body mass index, kg/m2 | 0.247 | 0.090 | 0.675 | 0.386 | ||||||
| < 25 | 11/103 | 1 | 1 | 19/117 | 1 | 1 | ||||
| 25–30 | 21/110 | 1.28 (0.61-2.69) | 0.75 (0.23–2.49) | 29/127 | 0.98 (0.52–1.87) | 1.05 (0.47–2.36) | ||||
| ≥ 30 | 27/91 | 1.79 (0.87–3.67) | 2.05 (0.78–5.36) | 26/92 | 1.24 (0.64–2.40) | 1.59 (0.71–3.56) | ||||
| Per 5.0 U | 59/304 | 1.24 (0.97–1.58) | 0.084 | 1.43 (1.02–2.00) | 0.038 | 74/336 | 1.18 (0.93–1.49) | 0.169 | 1.28 (0.97–1.68) | 0.083 |
| Waist circumference, cm | 0.099 | 0.147 | 0.073 | 0.221 | ||||||
| < 88 | 15/136 | 1 | 1 | 19/137 | 1 | 1 | ||||
| ≥ 88 | 43/166 | 1.66 (0.89–3.10) | 2.00 (0.79–5.09) | 50/185 | 1.66 (0.94–2.95) | 1.51 (0.77–2.97) | ||||
| Per 10 U | 58/302 | 1.28 (1.05–1.55) | 0.013 | 1.41 (1.07–1.86) | 0.016 | 69/322 | 1.18 (1. 01–1.38) | 0.034 | 1.22 (1.01–1.46) | 0.036 |
| Waist-to-hip ratio | 0.058 | 0.318 | 0.104 | 0.301 | ||||||
| ≤ 0.85 | 9/103 | 1 | 1 | 15/108 | 1 | 1 | ||||
| > 0.85 | 49/198 | 2.10 (0.97–4.52) | 1.62 (0.60–4.39) | 54/194 | 1.63 (0.89–3.00) | 1.44 (0.71–2.91) | ||||
| Per 0.1 U | 58/301 | 1.74 (1.28–2.39) | 0.001 | 1.92 (1.27–2.90) | 0.002 | 69/322 | 1.13 (0.86–1.48) | 0.388 | 1.08 (0.77–1.53) | 0.654 |
| Metabolic syndrome (MetS) | 0.002 | 0.023 | 0.885 | 0.890 | ||||||
| No | 18/164 | 1 | 1 | 36/193 | 1 | 1 | ||||
| Yes | 25/58 | 2.84 (1.47–5.48) | 2.81 (1.15–6.86) | 19/60 | 1.04 (0.58–1.89) | 1.05 (0.50–2.23) | ||||
| MetS components | 0.036 | + | 0.193 | 0.059 | 0.158 | |||||
| None | 0/37 | 4/44 | 1 | 1 | ||||||
| None+1–2 | 15/135 | 1 | 1 | 30/121 | 3.07 (1.07–8.81) | 2.91 (0.85–9.90) | ||||
| ≥ 3 | 25/58 | 2.98 (1.52–5.88) | 0.002 | 2.80 (1.14–6.88) | 0.03 | 19/60 | 1.02 (0.56–1.86) | 0.9 | 2.44 (0.66–9.04) | |
*HR adjusted by terms of: age (≤ 40, 41–60, > 60), center (Pascale, Policlinico), Stage (I–IIA, IIB, IIIA–IIIC).
**For the entire variable the p-value refers to Wald Test, for numerical variable z-Test p-value was reported. +model was not implemented due to absence of events in reference category.
Significant results are shown in bold.