Table 2.

Cluster sizes, center of mass coordinates and test statistic values of regions identified in the analyses.

Effect	Seed	Label	Size (voxels)	Peak x	Peak y	Peak z	Statistic
Group × treatment × region interaction (Fig. 2)	All	Right insula	28	−58.0	+9.0	+11.0	χ2 = 18.1
		Anterior vmPFC	42	+0.0	−53.0	−11.0	χ2 = 18.0
Main effect of group	All	Nil
Main effect of treatment	All	Nil
Main effect of region	All	See Fig. 1B
Main effect of order	All	Nil
Group × order interaction	All	Nil
Group × treatment interaction (Fig. 3)	sgACC (BA24/25)	Right hippocampus and parahippocampal gyrus	29	−38.0	+30.0	−14.0	Z = −3.56
		Anterior vmPFC	46	+7.0	−52.0	−12.0	Z = 3.50
	pgACC (BA24/32)	Dorsal posterior cingulate cortex	69	+0.0	+63.0	+40.0	Z = −2.60
		Ventral posterior cingulate cortex	33	−1.0	+37.0	+35.0	Z = −2.85
	dACC (BA8/32)	Left supramarginal gyrus	26	+56.0	+22.0	+39.0	Z = 3.95
TRD, effect of treatment (Figs. 4 and S2)	All	Nil
	sgACC (BA24/25)	Right hippocampus and parahippocampal gyrus	24	−40.0	+33.0	−15.0	Z = -3.07
		pgACC (BA24/32)	32	−2.0	−36.0	+5.0	Z = 2.91
		Anterior vmPFC	61	+4.0	−53.0	−12.0	Z = 3.79
		Right ventral striatum	37	−17.0	−2.0	−4.0	Z = 5.28
	pgACC (BA24/32)	Nil
	dACC (BA8/32)	Nil
HV, effect of treatment	All	Dorsal and ventral posterior cingulate cortex	45	+0.0	+46.0	+41.0	Z = 3.64
	sgACC (BA24/25)	Nil
	pgACC (BA24/32)	Ventral posterior cingulate cortex	156	−1.0	+33.0	+35.0	Z = 3.87
		Right dorsal posterior cingulate cortex	34	−11.0	+65.0	+34.0	Z = 4.65
		Left dorsal posterior cingulate cortex	35	+15.0	+63.0	+31.0	Z = 4.06
	dACC (BA8/32)	Nil
TRD, Treatment × SHAPS (Fig. 5A)	sgACC (BA24/25)	dACC	48	−2.0	−28.0	+35.0	Z = 5.18
Effect of SHAPS post-ketamine, controlled for placebo (Fig. 5B)	sgACC (BA24/25)	dACC	43*	−1.0	−8.0	+30.0	t = 3.65

Coordinates are in RAI format, in MNI space. Clusters reported at α < 0.05, with a cluster forming threshold of p < 0.001 and an extent of 24 voxels, except *reported at a threshold of p < 0.005.