Table 1.
Characteristics of BM aspirated samples.
| Characteristic | All samples (n = 351) | MGUS (n = 128) | SMM (n = 186) | MM (n = 37) |
|---|---|---|---|---|
| age, median (range) | 69 (43–89) | 69 (43–88) | 68 (44–88) | 70 (49–89) |
| sex (%) | 63% M - 37% F | 43% M - 57% F | 64% M - 36% F | 78% M - 22% F |
| Type, no. (%) | ||||
| IgG | 167 (47.6%) | 68 (53.1%) | 81 (43.5%) | 18 (48.6%) |
| IgA | 94 (26.8%) | 30 (23.4%) | 58 (31.2%) | 6 (16.2%) |
| biclonal | 30 (8.5%) | 12 (9.4%) | 15 (8.1%) | 3 (8.1%) |
| light-chaina | 60 (17.1%) | 18 (14.1%) | 32 (17.2%) | 10 (27.0%) |
| M-proteinb (g/dL), median (IQR) | 5.0 (1.0-11.0) | 1.0 (0.2-3.0) | 7.3 (4.0-13.0) | 16.2 (8.0-53.0) |
| FLC ratioc, median (IQR) | 15.6 (5.3-53.1) | 3.2 (2.1-4.6) | 19.1 (12.0-41.3) | 183 (131-321) |
| BMPCd (%), median (IQR) | 13% (8%-26%) | 8% (3%-8%) | 18% (16%-26%) | 51% (33%-66%) |
| BM sample pull, no (%) | ||||
| first | 219 (62.4%) | 44 (34.4%) | 143 (76.9%) | 32 (86.5%) |
| second | 132 (37.6%) | 84 (65.6%) | 43 (23.1%) | 5 (13.5%) |
MGUS monoclonal gammopathy of undetermined significance, SMM smoldering multiple myeloma, MM multiple myeloma, Ig immunoglobulin, BM bone marrow, M monoclonal, FLC free light-chain, BMPC bone marrow plasma cells, IQR Interquartile range. aLight-chain monoclonal gammopathy (abnormal light-chain levels and no detected M-protein); btotal serum M-protein concentration for individuals with identified M-protein; cFLC ratio (involved/uninvolved) for individuals with light-chain monoclonal gammopathy; dBMPC count by aspirate and biopsy with the higher value used (available for 336/351 samples).