Table 2.

Significant within-condition changes in personality outcomes

Outcome	Time	B	Confidence Interval	dz	ds
Escitalopram Treatment
Neuroticism	Baseline & Week 6	−0.38**	95%(−0.53 to −0.23)	−0.92	−0.44
Neuroticism	Baseline & Month 6	−0.46**	99% (−0.76 to −0.16)	−0.89	−0.51
Openness	Baseline & Week 6	0.28**	99% (0.04–0.51)	0.59	0.30
Intellect	Baseline & Week 6	0.28**	99% (0.06–0.50)	0.64	0.24
Disagreeableness	Baseline & Week 6	−0.26*	95% (−0.45 to −0.08)	−0.53	−0.33
Impulsivity	Baseline & Week 6	−0.35**	95% (−0.22 to −0.48)	−0.99	−0.49
Psilocybin Therapy
Neuroticism	Baseline & Week 6	−0.54**	95% (−0.82 to −0.26)	−0.70	−0.49
Neuroticism	Baseline & Month 6	−0.47*	99% (−0.92 to −0.03)	−57	−0.42
Introversion	Baseline & Week 6	−0.38**	95% (−0.57 to −0.19)	−0.73	−0.27
Openness	Baseline & Week 6	0.23′	95% (0.05–0.42)	0.46	0.22
Aesthetic Openness	Baseline & Week 6	0.27′	95% (0.05–0.48)	0.45	0.26
Intellect	Baseline & Week 6	0.22′	95% (0.03–0.41)	0.43	0.21
Absorption	Baseline & Week 6	0.30**	99% (0.11–0.50)	0.78	0.26
Disagreeableness	Baseline & Week 6	−0.47**	95% (−0.69 to −0.26)	−0.81	−0.45
Disagreeableness	Baseline & Month 6	−0.41**	99% (−0.74 to −0.07)	−0.67	−0.35
Impulsivity	Baseline & Week 6	−0.40**	95% (−0.30 to −0.51)	−1.39	−0.77

Note. Unstandardized (B) coefficients indicate mean differences between timepoints. dz indicates effect size change in outcome scores in terms of the standard deviation of within-subject change scores (e.g. T2-T1; Lakens, 2013). Cohen’s ds (standard Cohen’s d; Cohen, 1988) effect size estimates were calculated using the following equation: (Mean-score_T2 – Mean-score_T1)/[(SD_T1)2 + SD_T2)2] 0.5.

^′p < 0.05

^*p < 0.01

^**p < 0.005.