Table 4.

Plasma biomarker logistic regression ROC curve, F1, and P-value.

Protein	AKI (COVID-19) versus control			CKD/ESKD versus control
	ROC curve AUC (95%CI)	F1	P-value	ROC curve AUC (95%CI)	F1	P-value
KIM-1	1.00 (1.00–1.00)	1.00	0.003	0.80 (0.80–0.81)	0.80	0.282
NAG	0.60 (0.59–0.61)	0.32	1.000	0.51 (0.51–0.51)	0.84	1.000
Calbindin	0.99 (0.98–0.99)	0.90	0.026	0.77 (0.76–0.77)	0.81	0.577
GSTA1	1.00 (1.00–1.00)	0.96	0.003	0.76 (0.76–0.77)	0.80	0.666
Osteoactivin	0.91 (0.91–0.92)	0.75	0.062	0.86 (0.85–0.87)	0.89	0.026
Renin	1.00 (1.00–1.00)	0.99	0.003	0.91 (0.91–0.91)	0.88	0.006
Clusterin	0.94 (0.93–0.94)	0.66	0.039	0.83 (0.83–0.84)	0.84	0.104
RBP4	0.50 (0.48–0.52)	0.32	0.434	0.50 (0.49–0.52)	0.40	1.000
IL-18	1.00 (1.00–1.00)	0.96	0.003	0.92 (0.91–0.92)	0.89	0.015
IP-10	1.00 (1.00–1.00)	0.96	0.003	0.85 (0.84–0.86)	0.88	0.048
EGF	1.00 (1.00–1.00)	0.99	0.019	0.77 (0.77–0.78)	0.80	0.586
MCP-1	1.00 (1.00–1.00)	0.92	0.003	0.96 (0.96–0.96)	0.93	< 0.001
VEGF-A	1.00 (1.00–1.00)	0.99	0.003	0.94 (0.94–0.95)	0.93	0.001
Uromodulin	0.73 (0.72–0.74)	0.64	1.000	0.97 (0.97–0.97)	0.92	0.003
α1-microglobulin	0.64 (0.62–0.65)	0.53	1.000	0.96 (0.96–0.97)	0.92	< 0.001
TFF3	0.98 (0.98–0.99)	0.89	0.007	0.97 (0.96–0.97)	0.96	0.003
Osteopontin	1.00 (1.00–1.00)	1.00	0.003	0.92 (0.91–0.92)	0.89	0.005
Cystatin C	0.90 (0.89–0.91)	0.76	0.098	0.97 (0.97–0.97)	0.94	< 0.001
NGAL	0.95 (0.95–0.96)	0.87	0.023	0.96 (0.96–0.96)	0.95	< 0.001
β2-microglobulin	1.00 (1.00–1.00)	0.98	0.003	0.98 (0.98–0.98)	0.96	< 0.001
TIMP-1	1.00 (1.00–1.00)	1.00	0.003	0.97 (0.97–0.97)	0.93	< 0.001

p-value—Bonferroni Corrected Mann–Whitney.

Bold indicates statistically significant P values.