Table 1.
Characteristics of study population.
| SCD at steady state n = 151 | SCD during VOC n = 31 | p value | |
|---|---|---|---|
| Clinical characteristics | |||
| Age (years) | 35.6 ± 11.8 | 31.3 ± 9.1 | 0.041 |
| Male n (%) | 70 (46.4) | 16 (51.6) | 0.69 |
| Hydroxyurea n (%) | 83 (54.9) | 22 (70.9) | 0.11 |
| Osteonecrosis n (%) | 51 (33.7) | 4 (12.9) | 0.03 |
| Retinopathy n (%) | 36 (23.8) | 12 (38.7) | 0.11 |
| Vasculopathy n (%) | 24 (15.9) | 5 (16.1) | > 0.99 |
| ACS n (%) | 57 (37.8) | 9 (29) | 0.41 |
| Cholecystectomy n (%) | 69 (45.7) | 9 (29.0) | 0.11 |
| Splenectomy n (%) | 5 (3.3) | 5 (16.1) | 0.01 |
| S/S–S/β0 | 62 (41.06) | 18 (58.06) | 0.11 |
| S/Sα3.7 | 41 (27.15) | 6 (19.35) | 0.49 |
| S/C – S/β+ | 48 (31.79) | 7 (22.58) | 0.39 |
| Blood counts | |||
| RBC (1012/L) | 3.16 [2.70–4.09] | 2.79 [2.44–3.59] | 0.014 |
| Hemoglobin (g/dL) | 9.5 [8.1–10.6] | 9.0 [8.0–10.2] | 0.31 |
| Hematocrit (%) | 28.0 [23.7–32.0] | 25.0 [23.0–29.0] | 0.19 |
| MCV (fL) | 83.3 [75.1–92.4] | 91.0 [79.9–99.3] | 0.036 |
| MCHC (g/dL) | 34.5 [33.0–35.6] | 34.9 [33.8–35.8] | 0.12 |
| Platelets (109/L) | 302 [187–399] | 310 [248–399] | 0.16 |
| Leukocytes (109/L) | 7.3 [5.6–9.4] | 10.5 [8.0–12.3] | < 0.001 |
| Neutrophils (109/L) | 3.90 [2.72–5.15] | 5.65 [4.11–7.46] | < 0.001 |
| Lymphocytes (109/L) | 2.30 [1.54–3.04] | 2.64 [1.98–3.55] | 0.075 |
| Monocytes (109/L) | 0.69 [0.48–1.02] | 0.88 [0.55–1.31] | 0.036 |
| Hemolysis parameters | |||
| Reticulocytes (109/L) | 188.8 [137.8–296.7] | 288.1 [183.8–383.2] | 0.008 |
| Total bilirubin (µmol/L) | 25.0 [17.5–44.0] | 36.0 [18.5–50.0] | 0.18 |
| Indirect bilirubin (µmol/L) | 24.5 [16.0–37.5] | 29.0 [18.0–44.0] | 0.42 |
| LDH (U/L) | 342 [243–448] | 431 [364–502] | 0.01 |
| HI (UA/L) | 8 [1–17] | 12 [8–42] | 0.0043 |
| Biochemistry parameters | |||
| CRP (mg/L) | 5.0 [2.0–8.5] | 14.0 [6.0–20.0] | 0.0015 |
| Urea (mmol/L) | 3.1 [2.4–4.2] | 3.3 [2.2–4.1] | 0.72 |
| Creatinine (µmol/L) | 59 [50–72] | 53 [41–81] | 0.2 |
| Proteinemia (g/L) | 78.0 [74.5–81.0] | 76.0 [70.0–77.0] | 0.007 |
| ALP (U/L) | 72.5 [59.0–99.5] | 85.0 [62.0–123.0] | 0.33 |
| ASAT (U/L) | 35.5 [26.8–48.0] | 43.0 [35.5–62.5] | 0.022 |
| ALAT (U/L) | 22.0 [15.0–32.3] | 31.0 [20.0–66.0] | 0.032 |
| yGT (U/L) | 36.0 [24.0–73.0] | 57.5 [22.5–109.5] | 0.24 |
Data are expressed as median and [IQR] except for age (mean ± SD) and clinical characteristics with n is the total number of patients (%). ACS, acute chest syndrome; RBC, red blood cells; MCV, mean corpuscular volume; MCHC, mean corpuscular hemoglobin concentration; LDH, lactate dehydrogenase; HI, Hemolysis Index; CRP, C-reactive protein; ALP, alkaline phosphate; ASAT, aspartate amino transferase; ALAT, alanine amino transferase; yGT, gamma-glutamyl transferase.
Significant values are in [bold].