Table 2.
Comparison of biologic parameters in SCD patients developing or not VOC within 1 year.
| SCD at steady state without VOC development n = 110 | SCD at steady state with VOC development n = 41 | p value | |
|---|---|---|---|
| Hydroxyurea n (%) | 51 (46.4) | 32 (78) | 0.004 |
| Blood counts | |||
| RBC (1012/L) | 3.24 [2.82–4.25] | 3.02 [2.52–3.73] | 0.027 |
| Hemoglobin (g/dL) | 9.75 [8.40–10.68] | 8.75 [7.90–10.08] | 0.07 |
| Hematocrit (%) | 28 [24–32] | 26 [23–30] | 0.07 |
| MCV (fL) | 81.3 [72.9–90.8] | 84.2 [80.9–95.1] | 0.086 |
| MCHC (g/dL) | 34.7 [33.0–35.7] | 34.3 [32.9–35.5] | 0.69 |
| Platelets (109/L) | 290 [182–367] | 340 [199–40+] | 0.10 |
| Leukocytes (109/L) | 7.1 [5.7–8.7] | 7.6 [5.110.0] | 0.18 |
| Neutrophils (109/L) | 3.85 [2.71–4.98] | 4.09 [3.11–6.28] | 0.09 |
| Lymphocytes (109/L) | 2.30 [1.53–3.03] | 2.20 [1.62–3.17] | 0.77 |
| Monocytes (109/L) | 0.67 [0.46–0.97] | 0.78 [0.51–1.04] | 0.31 |
| Hemolysis parameters | |||
| Reticulocytes (109/L) | 161 [121–275] | 284 [201–367] | 0.0004 |
| Total bilirubin (µmol/L) | 25.0 [17.0–42.3] | 25.0 [18.0–46.0] | 0.62 |
| Indirect bilirubin (µmol/L) | 25.0 [15.75–38.25] | 24.0 [18.75–37.50] | 0.56 |
| LDH (U/L) | 323 [213–417] | 410 [311–530] | 0.0073 |
| HI (UA/L) | 6.5 [5.0–16.0] | 11.0 [5.0–21.0] | 0.04 |
| Biochemistry parameters | |||
| CRP (mg/L) | 5.0 [3.0–7.5] | 6.0 [2.3–10.8] | 0.31 |
| Ferritin (µg/L) | 114 [48–274] | 161 [83–298] | 0.33 |
| Urea (mmol/L) | 3.15 [2.40–4.58] | 2.85 [2.30–3.60] | 0.11 |
| Creatinin (µmol/L) | 63.0 [53.0–79.8] | 55.0 [46.8–63.3] | 0.0072 |
| Proteinemia (g/L) | 78 [75–81] | 77 [73–81] | 0.30 |
| ALP (U/L) | 69.5 [58.0–100.3] | 78.0 [64.8–95.0] | 0.49 |
| ASAT (U/L) | 34 [26–48] | 38 [31–48] | 0.41 |
| ALAT (U/L) | 23 [15–34] | 20 [14–28] | 0.28 |
| yGT (U/L) | 36 [24–74] | 31 [21–73] | 0.71 |
Data are expressed as median and [IQR], n is the total number of patients. RBC, red blood cells; MCV, mean corpuscular volume; MCHC, mean corpuscular hemoglobin concentration; LDH, lactate dehydrogenase; HI, Hemolysis Index; CRP, C-reactive protein; ALP, alkaline phosphate; ASAT, aspartate amino transferase; ALAT, alanine amino transferase; yGT, gamma-glutamyl transferase; VOC, vaso-occlusive crisis.
Significant values are in [bold].