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. 2023 Jul 11;13(12):4840–4855. doi: 10.1016/j.apsb.2023.07.006

Figure 1.

Figure 1

ADAR1 was highly expressed in the lung tissues of PH patients and hypoxic mice. (A) The expression of ADAR1 in PH was analyzed with GEO database (GSE113439). (B–C) Western blotting analysis showing that ADAR1 expression was upregulated in the lung tissues of PH patients (B, n = 6) and SuHx-induced PH mice (C, n = 5). (D, E) Immunofluorescence (D) and immunohistochemistry (E) assays showing the expression and distribution of ADAR1 in the lung tissues of PH patients, n = 6. (F, G) Representative Western blots and group data showing the expression of ADAR1 in human PAECs and PASMCs, n = 6. (H) qPCR analysis showing the mRNA expression of ADAR1 in PASMCs, n = 6. (I) Immunofluorescence assay showing the subcellular localization of ADAR1 in PASMCs, n = 6. PASMCs, pulmonary artery smooth muscle cells; PAECs, pulmonary artery endothelial cells; CON (C), control; PH (P), Pulmonary hypertension; NOR, normoxia; HYP, hypoxia. SuHx, Hypoxia combined with Su5416, ns, no significance; H, h; Statistical analysis was performed with one-way ANOVA followed by Dunnett's test or the Student's t-test; All values are presented as mean ± SEM. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001.