Table 5.
In vivo pharmacokinetic parameters of 29c in female micea.
| Route | Dose (mg/kg) | t1/2 (h) | Tmax (h) | Cmax (μg/mL) | AUC (h·μg/mL) | CL (mL/min/kg) | Vss (L/kg) |
|---|---|---|---|---|---|---|---|
| iv | 2 | 2.77 | 0.083 | 1.42 | 1.21 | 27.67 | 4.5 |
| ip | 4 | 6.38 | 0.167 | 0.352 | 0.96 | – | – |
| po | 20 | 5.81 | 0.5 | 0.153 | 0.36 | – | – |
a
Three plasma samples at each time point. t1/2, half-life time; Tmax, the maximum concentration of time point; Cmax, compound maximum concentration in plasma samples; AUC, area under the concentration curve in plasma samples; CL, plasma clearance rate; Vss, steady state volume of distribution; iv, intravenous administration; ip, intraperitoneal; po, oral administration.