Table 2.
Number of Events and Incidence of Hypoglycemia in 1:1 PS Matched Cohorts of SGLT2i and DPP-4i (GLP-1RA) Initiators
| Comparison | Outcomes | Number of Matched Pairs | SGLT2i Initiators | Comparator Initiators | Rate Differences Per 1 000 PY (95% CI) | Hazard Ratios (95% CI) |
|---|---|---|---|---|---|---|
| No. of events (rate/1 000 PY) | No. of events (rate/1 000 PY) | |||||
| SGLT2i vs DPP-4i | Hypoglycemia (inpatient + ED) | 82,994 | 692 (9.8) | 987 (13.0) | −3.21 (−4.29, −2.12) | 0.75 (0.68, 0.83) |
| Hypoglycemia (inpatient) | 82,994 | 77 (1.1) | 96 (1.0) | −0.17 (−0.52, 0.18) | 0.87 (0.65, 1.18) | |
| Hypoglycemia (ED) | 82,994 | 689 (9.7) | 986 (13.0) | −3.24 (−4.33, −2.15) | 0.75 (0.68, 0.83) | |
| SGLT2i vs GLP-1RA | Hypoglycemia (inpatient + ED) | 88,726 | 848 (11.1) | 898 (12.5) | −1.33 (−2.44, −0.23) | 0.90 (0.82, 0.98) |
| Hypoglycemia (inpatient) | 88,726 | 92 (1.2) | 75 (1.0) | 0.17 (−0.17, 0.51) | 1.16 (0.85, 1.57) | |
| Hypoglycemia (ED) | 88,726 | 842 (11.1) | 896 (12.4) | −1.38 (−2.49, −0.28) | 0.89 (0.81, 0.98) |
Note: DPP4i = dipeptidyl peptidase-4 inhibitors; ER = emergency room; GLP-1RA = glucagon-like peptide-1 receptor agonist; PS = propensity-score; PY = person-years; SGLT2i = sodium-glucose cotransporter 2 inhibitors.