Table 3.

Multivariable Associations of Weight Change With Survival to Age 95 vs Death Before Age 95 Among Older Women, 1993 to 2022

Variable	No./Total (%) Survived to Age 95, y*	OR (95% CI)†
No./total (%) survived to age 95	8 140/28 014 (29.1)
3-Y weight change
Stable weight (within ± 5% change)	5 974/19 098 (31.3)	1.00
Weight loss (≥5%)	1 123/5 191 (21.6)	0.65 (0.60, 0.71)
Intentional‡	166/687 (24.2)	0.77 (0.63, 0.94)
Unintentional‡	175/1 096 (16.0)	0.44 (0.37, 0.53)
Weight gain (≥5%)	1 043/3 725 (28.0)	0.94 (0.86, 1.02)
10-Y weight change
Stable weight (within ± 5% change)	562/1 476 (38.1)	1.00
Weight loss (≥5%)	342/1 347 (25.4)	0.51 (0.41, 0.63)
Weight gain (≥5%)	174/501 (34.7)	0.85 (0.64, 1.12)

^*Three-year and 10-year weight change categories significantly differed by survival to age 95 (p < .001).

^†Models adjusted for age, study component (Observational Study [OS] or Clinical Trial), race, ethnicity, education, marital status, alcohol, smoking, diet quality, physical activity, physical function, body mass index, coronary heart disease, diabetes, stroke, cancer, emphysema, and hypertension.

^‡Intention of weight loss was reported at year 3 among women from the OS component only.