Table 1.
Characteristic | Standard care N = | Nitric oxide N = |
---|---|---|
Age at randomisation (weeks),⁎ median (IQR) | ||
< 6 weeks, n (%) | ||
≥ 6 weeks, n (%) | ||
Weight (kg), median (IQR) | ||
Female sex, n (%) | ||
Ethnicity, n (%) | ||
Caucasian | ||
Aboriginal/Torres Strait Islander | ||
Asian | ||
Mãori/Pacific Islander | ||
Mixed/other | ||
Congenital heart disease, n (%) | ||
Univentricular⁎ | ||
Biventricular⁎ | ||
History of previous cardiac surgery on CPB | ||
Right-sided obstructive lesions | ||
Tetralogy of Fallot | ||
Double outlet right ventricle | ||
Pulmonary stenosis/atresia | ||
Tricuspid stenosis/atresia | ||
Other | ||
Left-sided obstructive lesions | ||
Coarctation | ||
Interrupted aortic arch | ||
Hypoplastic aortic arch | ||
HLHS | ||
Other | ||
Shunt lesions | ||
ASD | ||
VSD | ||
AVSD | ||
Truncus | ||
TGA | ||
Persistent ductus arteriosus | ||
Other | ||
Various lesions | ||
Double-inlet left ventricle | ||
TAPVD | ||
Other | ||
Current ICU admission and treatments before heart surgery | ||
Intensive care admission, n (%) | ||
Duration of ICU stay (days), median (IQR) | ||
Treatments | ||
Invasive ventilation, n (%) | ||
Duration of invasive ventilation (days), median (IQR) | ||
Tracheostomy, n (%) | ||
Inotropes, n (%) | ||
Prostaglandin, n (%) | ||
Steroids, n (%) | ||
Afterload reducing agents, n (%) | ||
Inhaled nitric oxide, n (%) | ||
Sildenafil, n (%) | ||
Comorbidities, n (%) | ||
POPC | ||
Good/normal | ||
Functionally normal | ||
Mild overall disability | ||
Moderate overall disability | ||
Severe overall disability | ||
Coma/vegetative state | ||
Brain death | ||
Unknown | ||
Congenital syndrome | ||
Trisomy 21 | ||
22q11 | ||
Turner | ||
Noonan | ||
VACTERL | ||
CHARGE | ||
Other syndrome | ||
Country of hospital, n (%) | ||
Australia | ||
New Zealand | ||
The Netherlands | ||
Surgical complexity | ||
RACHS score, median (IQR) | ||
RACHS-1, n (%) | ||
RACHS-2, n (%) | ||
RACHS-3, n (%) | ||
RACHS-4, n (%) | ||
RACHS-5, n (%) | ||
RACHS-6, n (%) | ||
Surgical procedure, n (%) | ||
Tetralogy repair | ||
Norwood procedure | ||
Bicavopulmonary shunt | ||
Right ventricular to pulmonary artery shunt/conduit | ||
Fontan completion | ||
Arterial switch operation | ||
ASD repair | ||
VSD repair | ||
AVSD repair | ||
Aortic arch repair | ||
Coarctation repair | ||
Truncus repair | ||
Pulmonary artery band | ||
Ross procedure | ||
Left ventricular outflow tract surgery | ||
Right ventricular outflow tract surgery | ||
Valve surgery | ||
Valve repair | ||
Anomalous pulmonary vein repair | ||
Heart transplant | ||
Other |
ASD = atrial septal defect; AVSD = atrioventricular septal defect; CHARGE = coloboma, heart defects, atresia choanae (also known as choanal atresia), growth retardation, genital abnormalities, and ear abnormalities; CPB = cardiopulmonary bypass; HLHS = hypoplastic left heart syndrome; ICU = intensive care unit; IQR = interquartile range; POPC = Pediatric Overall Performance Category; RACHS = Risk Adjustment for Congenital Heart Surgery; TAPVD = total anomalous pulmonary venous drainage; TGA = transposition of the great arteries; VACTERL = vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, and limb abnormalities; VSD = ventricular septal defect.
Used for stratification.