Table 3.

Primary and secondary outcomes per intention-to-treat analysis

Outcome	Standard care N =	Nitric oxide N =	Unadjusted P	Estimate of difference (95% CI)	Adjusted P
Primary outcome
Ventilator-free days, median (IQR)
Secondary outcomes
Duration of invasive ventilation (days), median (IQR)
Low cardiac output syndrome (need for ECLS, or death), n (%)
Low cardiac output syndrome
ECLS
Death
Length of stay in PICU (days), median (IQR)
Length of stay in hospital (days), median (IQR)
Process of care measures
Duration of time with open chest after the operation (hours), median (IQR)
Treated with inhaled NO after the operation, n (%)
►Duration of inhaled NO (hours), median (IQR) Treated with renal replacement after the operation, n (%) ►Duration of renal replacement therapy (hours), median (IQR)
Physiological descriptors
Organ dysfunction after the operation (PELOD-2 score), median (IQR)
►PICU admission ►24 hours ►48 hours
Troponin after the operation, median (IQR)
►PICU admission ►24 hours after PICU admission
Creatinine, mean (SD)
►PICU admission ►24 hours post-PICU admission
AKI: PICU admission, n (%)
►Stage 1 ►Stage 2 ►Stage 3
AKI: 24 hours, n (%)
►Stage 1 ►Stage 2 ►Stage 3
AKI: 48 hours, n (%)
►Stage 1 ►Stage 2 ►Stage 3

AKI = acute kidney injury; ECLS = extracorporeal life support; IQR = interquartile range; NO = nitric oxide; PELOD-2 = Paediatric Logistic Organ Dysfunction-2; PICU = paediatric intensive care unit; SD = standard deviation.