Table 2.

Thyroid function parameters and urinary excretion of oxidative stress markers in hypothyroid women and healthy control subjects. Thyroid function parameters are given as mean ± s.d., and the oxidative stress markers are presented as geometric mean with a 95% CI. The mean difference (with 95% CI) between baseline and follow-up is a relative measure as the oxidative stress markers are logarithmically transformed.

	Patients (n = 45)				Controls (n = 18)	Pb
	Baseline	Follow-up	Mean difference	Pa
TSH (mIU/L)	21.89 ± 35.04	2.11 ± 1.84		<0.001	1.74 ± 0.98
FT4 (pmol/L)	14.00 ± 5.01	18.10 ± 3.25		<0.001	14.47 ± 1.68
8-oxoGuo (nmol/mmol Cr)	1.63 (1.49–1.78)	1.67 (1.53–1.83)	0.97 (0.91–1.04)	0.39	1.23 (1.07–1.42)	<0.001
8-oxodG (nmol/mmol Cr)	1.28 (1.14–1.44)	1.32 (1.18–1.48)	0.97 (0.88–1.06)	0.47	1.04 (0.88–1.23)	0.03

^aPaired t-test comparing hypothyroid participants at baseline and follow-up; ^bIndependent t-test comparing oxidative stress markers in hypothyroid participants at follow-up with control subjects.

8-oxoGuo, 8-oxo-7,8-dihydroguanosine; 8-oxodG, 8-oxo-7,8-dihydro-2′-deoxyguanosine; Cr, creatinine; FT4, free thyroxine; TSH, thyrotropin.