Table 1.

Baseline characteristics of the participants according to thyroid hormone use.

	Nonusers (n = 142,664)	Thyroid hormone users (n = 4537)	P
Men/women	60,771/81,893	534/4003
% women	57.4	88.2	<0.001
Age (years)	44.6 ± 13.1	51.0 ± 12.8	<0.001
Body mass index (kg/m2)	26.0 ± 4.3	27.6 ± 5.3	<0.001
Systolic blood pressure (mmHg)	125 ± 15	126 ± 16	0.10
Diastolic blood pressure (mmHg)	74 ± 9	73 ± 9	<0.001
TSH (mU/L)a	2.1 (1.5–3.0)	2.3 (0.8–4.2)	0.24
FT4 (pmol/L)a	15.7 ± 2.1	18.2 ± 3.7	<0.001
FT3 (pmol/L)a	5.3 ± 0.7	4.7 ± 1.2	<0.001
Creatinine (umol/L)	73.6 ± 13.7	70.4 ± 14.4	<0.001
Fasting glucose (mmol/L)	5.0 ± 0.8	5.1 ± 1.1	<0.001
Total cholesterol (mmol/L)	5.1 ± 1.0	5.2 ± 1.0	<0.001
Hemoglobin (g/dL)
Men	15.1 ± 0.9	15.0 ± 1.1	<0.001
Women	13.5 ± 1.0	13.4 ± 1.0	0.005
Affected disease domains			<0.001
% with 0 affected disease domains	29.0	15.4
% with one affected disease domain	32.4	25.9
% with two affected disease domains	21.0	23.8
% with three affected disease domains	10.8	16.7
% with four affected disease domains	4.5	10.2
% with five affected disease domains	1.6	4.7
% with six affected disease domains	0.6	2.4
% with ≥7 affected disease domains	0.1	0.9

Data are represented as means ± s.d. (normal distribution), medians with interquartile ranges (nonnormal distribution) or percentages.

^aThyroid hormone levels were available of 39,786 participants (1145 thyroid hormone users and 38,711 nonusers).