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. 2023 Oct 20;299(12):105369. doi: 10.1016/j.jbc.2023.105369

Table 3.

Compounds Affecting TMR-FLT of cC0-C2, cC0-C2#P and fC1-C2

Compounds cC0-C2
cC0-C2#P
fC1-C2
FLT change FLT change cC0-C2/cC0-C2#P FLT change cC0-C2/fC1-C2
Erythromycin estolate −14.1% −2.4% 5.9 −2.1% 6.7
Clindamycin palmitate HCl −12.7% −10.2% 1.2 −1.2% 10.6
Scutellarin −9.1% −8.7% 1.0 −9.5% 1.0
Fidaxomicin −5.2% −0.5% 10.4 −4.3% 1.2
Fenticonazole nitrate −4.7% −6.0% 0.8 0.4% 11.8
Bedaquiline fumarate −4.5% −6.5% 0.7 6.7% 0.7
Fostamatinib (R788) 2.3% 0.7% 3.3 0.4% 5.8
Chloroquine phosphate 2.5% 3.1% 0.8 1.9% 1.3
Hederagenin 2.5% 3.6% 0.7 2.3% 1.1
Enoxaparin sodium 3.1% 6.9% 0.4 2.8% 1.1
Tocofersolan 3.3% 3.2% 1.0 2.8% 1.2
Tamibarotene 5.2% 7.2% 0.7 5.9% 0.9
Saikosaponin D 5.4% 6.3% 0.9 4.2% 1.3
Verteporfin∗ 5.5% 6.8% 0.8 2.5% 2.2
Troxerutin 6.1% 7.3% 0.8 6.0% 1.0
α-Hederin 6.7% 7.1% 0.9 6.7% 1.0
Cefsulodin sodium 9.1% 8.1% 1.1 11.5% 0.8
Febuxostat 9.6% 12.1% 0.8 14.6% 0.7
Erlotinib 9.8% 9.7% 1.0 8.5% 1.2
Nilotinib hydrochloride 10.1% 14.1% 0.7 15.6% 0.6
Ertapenem sodium 10.2% 8.0% 1.3 12.2% 0.8
Triclocarban 11.6% 18.2% 0.6 22.2% 0.5
Erlotinib HCl 11.8% 13.9% 0.8 11.1% 1.1
Pneumocandin B0 12.4% 13.2% 0.9 11.4% 1.1
Paritaprevir (ABT-450) 23.8% 20.3% 1.2 11.0% 2.2
Pranlukast 30.7% 50.1% 0.6 50.3% 0.6
Anidulafungin 32.1% 43.3% 0.7 53.0% 0.6

FLT change at 60 μM compound concentration is shown, except ∗ (10 μM). Effect (% change from DMSO) on FLT of TMR-MyBP-C. Compounds that did not affect cC0-C2 or fC1-C2 binding to actin (not in Tables 1 and 2) are underlined.