REAGENT or RESOURCE	SOURCE	IDENTIFIER
Chemicals, peptides, and recombinant proteins
Sardine Oil	Peru in 2019	N/A
cis-5,8,11,14,17-Eicosapentaenoic acid	Sigma-Aldrich	Cat# E2011
cis-4,7,10,13,16,19-Docosahexaenoic acid	Sigma-Aldrich	Cat# D2534
Isopropanol, Optima LC/MS grade	Fisher Scientific	Cat# A461-4
Methanol, Optima LC-MS grade	Fisher Scientific	Cat# A955-500
Acetonitrile, Optima LC-MS grade	Fisher Scientific	Cat# A955-500
Ethanol, HPLC grade	Fisher Scientific	Cat# AC611050040
Water, Optima LC-MS grade	Fisher Scientific	Cat# W6500
Tert-Butyl Methyl Ether, HPLC Plus grade	Sigma Aldrich	Cat# 650560
Ammonium formate	Alfa Aeser	Cat# 540-69-2
Butylated hydroxytoluene	Sigma Aldrich	Cat# B1378-100G
Acetic Acid, Optima LC/MS grad	Fisher Scientific	Cat# A11350
Phosphatidylcholine (23:0/23:0)	Avanti Polar Lipids	Cat# 850372
Phosphatidylglycerol (14:0/14:0)	Avanti Polar Lipids	Cat# 840445
Phosphatidic acid (14:0/14:0)	Avanti Polar Lipids	Cat# 830845
Phosphatidylethanolamine (14:0/14:0)	Avanti Polar Lipids	Cat# 850745
Phosphatidylserine (14:0/14:0)	Avanti Polar Lipids	Cat# 840033
Sphingomyelin (18:1/12:0)	Avanti Polar Lipids	Cat# 860583
Deuterated (d8)-Arachidonic acid	Cayman Chemical	Cat# 390010
Triglyceride (14:1/14:1/14:1)	NuCheck Prep	Cat# T-205
Liposome kit	Sigma-Aldrich	Cat# L4395-1VL
Oil red O	Poly Scientific, Inc	Cat# S-2146
Hematoxylin and eosin	Leica	Leica
(5Z,8Z,11Z,14Z,17Z)-Icosa-5,8,11,14,17-pentaenoic acid	Combi-Blocks	Cat# QG-5508
LiAlH4	MilliporeSigma	Cat# 199877
NaI	MilliporeSigma	Cat# 383112
Li2CuCl4	MilliporeSigma	Cat# 224308
Jones reagent	MilliporeSigma	Cat# 758035
RNeasy Mini Kit	Qiagen	Cat# 74004
TruSeq Stranded mRNA Sample Prep Kit	Illumina	Cat#: 20020595
Ketamine	Akorn, Inc	Cat# NDC42023-115-10
Xylazine	Akorn, Inc	Cat# NDC59399-110-20
1% tropicamide ophthalmic solution	Akorn, Inc	Cat# NDC17478-102-12
Deposited data
RNA-seq data	This paper	GEO: GSE221559
Experimental models: Cell lines
Chinese hamster ovary (CHO) cells	ATCC	CCL-61
Experimental models: Organisms/strains
Mouse: C57BL/6	Taconic Biosciences	B6NTac
Mouse: C57BL/6J	Jackson Laboratories	JAX:000664
Oligonucleotides
Cyp4a10 (Mm02601690_gH)	Life Technologies	Cat# 4331182
Cyp4a14 (Mm00484135_m1)	Life Technologies	Cat# 4331182
Cyp4a31 (Mm07308194_g1)	Life Technologies	Cat# 4351372
Acot1 (Mm01622471_s1)	Life Technologies	Cat# 4331182
Lpl (Mm00434764_m1)	Life Technologies	Cat# 4331182
Pck1 (Mm01247058_m1)	Life Technologies	Cat# 4331182
Pdhb (Mm00499323_m1)	Life Technologies	Cat# 4331182
C9 (Mm00442739_m1)	Life Technologies	Cat# 4331182
C4a (Mm01132415_g1)	Life Technologies	Cat# 4331182
Elovl2 (Mm00517086_m1)	Life Technologies	Cat# 4331182
Elovl5 (Mm00506717_m)	Life Technologies	Cat# 4331182
Actb (Mm02619580_g1)	Life Technologies	Cat# 4331182
Software and algorithms
NDP.view2	Hamamatsu Photonics	Cat# U12388-01
Optomotry VR, optomotor tests of vision	Cerebral Mechanics Inc.	Cat# Optomotry VR 1.7.4
ERG (UTAS visual diagnostic test system)	LKC technologies	Cat# EM for windows version 9.4.0
kallisto	Bray et al.36	https://github.com/pachterlab/kallisto
tximport	Soneson et al.37	https://bioconductor.org/packages/release/bioc/html/tximport.html
edgeR	Robinson et al.38	https://bioconductor.org/packages/release/bioc/html/edgeR.html
limma	Ritchie et al.39	https://bioconductor.org/packages/release/bioc/html/limma.html
gProfiler	Raudvere et al.40	https://biit.cs.ut.ee/gprofiler/gost
Pathview	Luo et al.41	https://bioconductor.org/packages/release/bioc/html/pathview.html
msigdb	Liberzon et al.42	https://www.gsea-msigdb.org/gsea/msigdb
MGI	Mouse Genome Database	https://www.informatics.jax.org/
tidyverse	R packages	https://www.tidyverse.org/
MAVEN metabolomics software v. 2.0.5	Life Technologies	Cat# NC2169324
LIMSA add-in for Microsoft Excel	N/A	www.helsinki.fi/science/lipids/software.html
MetaboAnalyst v. 5.0 software	N/A	www.metaboanalyst.ca
Other
Cobas® 6000 analyzer	Roche Diagnostics	Cat# ROCHE Cobas 6000
SuperoseTM 6 10/300 GL column	GE Healthcare	Cat# GE17-5172-01
ÄKTA pure™ chromatography system	GE Healthcare	Cat# 29018224
NanoDropTM spectrophotometer	Life Technologies	Cat# ND2000CLAPTOP
4200 TapeStation System	Agilent Technologies	Cat# G2991BA
NextSeq 2000	Illumina	Cat# 20038897
Hamamatsu NDP scanner	Hamamatsu Photonics	Cat# RS
Nuclear Magnetic Resonance Spectroscopy (NMR)	Agilent Technologies	Model: Varian INOVA 400
High-Resolution Mass Spectrometry (HRMS)	Waters Corp	Model: Xevo G2-XS QT
ERG instrument (Full field ERG, UTAS E 3000)	LKC technologies	Cat# UTAS E 3000
OptoMotry	CerebralMechanics Inc.	Optomotry, serial number DP/N 00324H
Fisher Bead Mill 4	Fisher Scientific	Cat# 15-340-164
Ceramic beads	Fisher Scientific	Cat# 15-340-185
Savant Speedvac SC110A	American Laboratory Trading	Cat# 23011
Vortex Genie II	Scientific Industries	Cat# SI-0236
Synergi HydroRP C18AQ 150 × 2 mm, 4 u, 80A LC-MS column	Phenomenex	Cat# 00F-4375-B0
C18AQ SecurityGuard cartridge	Phenomenex	Cat# AJ0-7510
Shimadzu Prominence HPLC	Prodigy Scientific	Cat# Shimadzu-Prom
Thermo LTQ-Orbitrap Velos mass spectrometer	Labexchange	Cat# 19984
Eppendorf Safe-Lock 2.0 mL tubes, PCR clean	Sigma Aldrich	Cat# EP022363344
Cat# EP022363344	Fisher Scientific	Cat# 06-406-19M
LC-MS vial snap-caps, 11 mm	Fisher Scientific	Cat# 14-823-399
Agilent vial inserts 250 ul	Agilent	Cat# 5183-2085
Bleaching Clay	Mizusawa Industrial Chemicals, Ltd.	Cat# GALLEON EARTH V2
Silica Gel	AGC Si-Tech Co., LTD	Cat# M.S.GEL D-75-60A