Table 3.

Association Between Isolated Diastolic Hypertension and Composite Kidney outcome

BP Phenotype	No. of Patients at Baseline in Each Category	No. of Events	Event Rate Per 1,000 Person-Y	Unadjusted	Model A	Model B	Model C
				HR (95% CI)
Normotension (reference group)	2,919	701	35	—	—	—	—
Isolated diastolic hypertension	347	107	41	1.16 (0.94-1.42); P = 0.16	0.93 (0.76-1.14); P = 0.5	1.20 (0.97-1.49); P = 0.1	1.17 (0.93-1.47); P = 0.17
Isolated systolic hypertension	1,447	568	82	2.41 (2.15-2.69); P < 0.001∗	2.44 (2.18-2.75); P < 0.001∗	1.97 (1.73-2.23); P < 0.001∗	1.44 (1.26-1.65); P < 0.001∗
Systolic diastolic hypertension	908	424	96	2.80 (2.48-3.16); P < 0.001∗	2.40 (2.12-2.71); P < 0.001∗	2.18 (1.91-2.50); P < 0.001∗	1.67 (1.45-1.93); P < 0.001∗

Note: Model A: adjusted for age (years), sex (men or women), race (non-Hispanic White, non-Hispanic Black, Hispanic, and others), and center (7 categories). Model B: adjusted for model A plus diabetes mellitus (yes or no), smoking status (never or past or current), cardiovascular disease (yes or no), BMI (kg/m²), antihypertensive medications, and low density lipoprotein cholesterol (mg/dL). Model C: adjusted for model B plus eGFR (mL/min/1.73 m²) and 24-hour urine protein.

Composite kidney outcome defined as 50% decrease in eGFR or end-stage kidney disease defined as kidney transplantation or start of long-term dialysis.

^∗P < 0.05