Table 3.
Effects of the herbal product on hematological parameters of rats in sub-acute toxicity test. The animals received the food supplemented with the powder of herbal product at doses of 600 or 1200 mg/kg/day for 28 days. At the end of the study, blood sampling was performed by cardiac puncture for a complete blood count. Data are shown as mean ± SEM (n = 6).
| Parameters | Animal sex | Study group |
||
|---|---|---|---|---|
| Control | 300 mg/kg | 600 mg/kg | ||
| RBC (×106/μL) | Female | 8.5 ± 0.2 | 8.2 ± 0.16 | 8.5 ± 0.1 |
| Male | 9 ± 0.1 | 8.6 ± 0.1 | 9 ± 0.1 | |
| Hemoglobin (g/dL) | Female | 14.4 ± 0.2 | 13.8 ± 0.1 | 14.2 ± 0.2 |
| Male | 14.8 ± 0.2 | 14.2 ± 0.2 | 14.9 ± 0.2 | |
| Hematocrit (%) | Female | 43.3 ± 1 | 42.4 ± 0.3 | 43.4 ± 1 |
| Male | 45 ± 0.4 | 42 ± 1 | 45 ± 1 | |
| MCV (fL) | Female | 51 ± 1 | 52 ± 1 | 51 ± 1 |
| Male | 49 ± 0.7 | 49 ± 0.6 | 50 ± 0.4 | |
| MCH (pg) | Female | 17 ± 0.1 | 17 ± 0.2 | 16.5 ± 0.1 |
| Male | 16.3 ± 0.3 | 16.5 ± 0.2 | 16.4 ± 0.2 | |
| MCHC (g/dL) | Female | 33 ± 0.2 | 32 ± 0.2 | 33 ± 0.2 |
| Male | 33 ± 0.1 | 33 ± 0.1 | 33 ± 0.2 | |
| Platelets (×103/μL) | Female | 973 ± 81 | 933 ± 58 | 1032 ± 42 |
| Male | 893 ± 51 | 898 ± 46 | 937 ± 23 | |
| WBC (×103/μL) | Female | 3.4 ± 0.5 | 3.7 ± 0.8 | 3.6 ± 0.6 |
| Male | 6 ± 0.5 | 7.7 ± 1.7 | 4.5 ± 1.1 | |
| Neutrophils (%) | Female | 24 ± 1.7 | 22 ± 2.5 | 22 ± 1.8 |
| Male | 26 ± 1.6 | 23 ± 3.5 | 30 ± 4.7 | |
| Lymphocytes (%) | Female | 75 ± 1.8 | 76 ± 2 | 77 ± 1.7 |
| Male | 74 ± 1.7 | 76 ± 3.5 | 70 ± 4.7 | |
| Monocytes (%) | Female | 0.6 ± 0.1 | 2.6 ± 2 | 0.4 ± 0.1 |
| Male | 0.06 ± 0.02 | 0.0 | 0.06 ± 0.02 | |
| Eosinophils (%) | Female | 0.0 | 0.06 ± 0.02 | 0.03 ± 0.02 |
| Male | 0.02 ± 0.02 | 0.02 ± 0.02 | 0.0 | |
| Basophils (%) | Female | 0.1 ± 0.05 | 0.1 ± 0.06 | 0.1 ± 0.06 |
| Male | 0.22 ± 0.1 | 0.3 ± 0.06 | 0.2 ± 0.07 | |
MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; MCV: mean corpuscular volume; RBC: red blood cell; WBC: white blood cells