Table 2.

BCR-ABL kinase mutations in ponatinib-resistant cells.

Cell line	Chromosome base pair position	Reference	Alternative	Effect of variant	HGVS.c
K562/PR	23,313,032	G	A	Intron variant	c.3457 + 11G > A
	23,316,021	C	G	3 prime UTR variant	c.*499C > G
	23,316,029	C	A	3 prime UTR variant	c.*507C > A
	23,316,087	T	TTTC	3 prime UTR variant	c.*568_*570dupCTT
	23,316,158	G	A	3 prime UTR variant	c.*636G > A
	23,316,174	T	C	3 prime UTR variant	c.*652T > C
	23,316,973	G	A	3 prime UTR variant	c.*1451G > A
	23,317,335	G	C	3 prime UTR variant	c.*1813G > C
	23,317,807	T	C	3 prime UTR variant	c.*2285T > C
KU812/PR	23,186,017	C	A	Intron variant	c.1279 + 3778C > A
	23,313,430	G	A	Intron variant	c.3457 + 409G > A
	23,313,452	C	G	Intron variant	c.3457 + 431C > G
	23,317,070	GCT	G	3 prime UTR variant	c.*1551_*1552delCT
	23,317,335	G	C	3 prime UTR variant	c.*1813G > C
	23,317,437	C	G	3 prime UTR variant	c.*1915C > G