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. 2023 Sep 14;39(6):992–996. doi: 10.1002/joa3.12921

TABLE 1.

Characteristics of studies in the meta‐analysis that investigate the association between periodontal disease and atrial fibrillation/atrial flutter.

First author/year Country Study design Patients (n) Study population/inclusion criteria Exclusion criteria Periodontal disease diagnosis Atrial fibrillation/atrial flutter diagnosis
Periodontal disease Nonperiodontal disease
Chen/2016 Taiwan A retrospective cohort 393 745 393 745 Participants from The Taiwanese National Health Insurance Research Database (NHIRD) included patients with PD and non‐PD that were individually matched with a 1:1 ratio based on gender and individual age Previous diagnoses of AF or AFL A diagnosis code (ICD9‐CM Codes 523.3–5) A diagnosis code (ICD9‐CM Codes 427.31–2)
Hsu/2022 Taiwan A retrospective cohort 282 560 282 560 Participants from The Taiwanese National Health Insurance Research Database (NHIRD) included patients with periodontitis and nonperiodontitis that were individually matched with a 1:1 ratio based on age, urbanization level, income, and index day Prior stroke A diagnosis code 523.X with subgingival curettage treatment code (91006–91 008) N/A
Sen/2021 United States A prospective cohort 4289 1669 Participants from the Atherosclerosis Risk in Communities (ARIC) Study Prior AF, participants with medical contraindications to a dental exam, those with dental implants only, not African American or white (because of limited sample size of other races) The periodontal profile class (PPC); periodontal health (PPC‐A), mild PD (PPC‐B and C), moderate PD (PPC‐D and E), and severe PD (PPCF and G) A standard 12‐lead ECG, hospitalization, and death certificates using ICD‐9‐CM codes 427.31 or 427.32