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A schematic of IL-6/JAK2 axis-dependent G6PD Y437 phosphorylation for OSCC proliferation.
IL-6 treatment rapidly activates JAK2, which in turn phosphorylates G6PD at Y437, leading to enhanced G6PD enzymatic activity. G6PD activation boosts PPP and R5P production, and so that facilitates DNA and RNA biosynthesis to support OSCC cell proliferation.
