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. 2023 Nov 16;4(4):102725. doi: 10.1016/j.xpro.2023.102725

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© 2023 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Comparison of oligodendrocytes in brain organoids with fetal brain OPCs/oligodendrocytes

(A) UMAP of single-cell RNA-sequencing of oligodendrocyte brain organoids showing the oligodendrocyte population (cluster 9) in the generated brain organoids.

(B) Dot plot showing the expression of selected markers of oligodendrocytes. Dot size represents the percentage of clusters expressing a specific marker, while the intensity of color indicates the average expression level for that gene, in that cluster.

(C) Integration of cluster 9 with fetal brain OPCs and oligodendrocytes clusters the generated cells (marked as CTL) with Oligo_3 forming the new cluster 0, while Oligo_1, Oligo_2, and Oligo_4 form clusters 3, 1, and 2 respectively.

(D) Heatmap based on marker genes for each of the five populations (CTL, Oligo_1, Oligo_2, Oligo_3, Oligo_4) reveals similar overall gene expression of CTL and Oligo_3.