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. 2023 Nov 30;19(11):1067–1074. doi: 10.6026/973206300191067

Table 3. Comparison of ADMET properties of triterpenoid compounds 1, 2 and 3 with paclitaxel.

Compound name Absorption Disrtibution Metabolism Excretion Toxicity
Intestinal absorption (human)(% Absorbed) BBB permeability (log BB) CYP2D6 substrate(Yes/No) CYP2D6 inhibitior Total Clearance (log ml/min/kg) AMES toxicity (Yes/No) Oral Rat Acute Toxicity (LD50) mol/kg) Oral Rat Chronic Toxicity (LOAEL)(log mg/kg_bw/day) Hepatotoxicity (Yes/No)
Paclitaxel 100 -1.731 No No 0.36 No 2.776 3.393 Yes
Triterpenoid Compound 1 98.782 -0.763 No No 0.586 No 2.7 2.073 Yes
Triterpenoid Compound 2 98.237 -0.716 No No 0.552 No 2.579 2.025 Yes
Triterpenoid Compound 3 98.565 -0.942 No No 0.602 No 3.007 2.309 Yes