Figure 2.

The proportion of cip^R mutant in replicate metapopulations propagated by either star (blue) or well-mixed (red) networks with unweighted migration. The bright lines depict the nonlinear least squares (NLS) fit for each metapopulation structure. Panel A shows experimental results; simulation results are shown in (B) and (C). Migration rates are noted in the inset of each plot. Migration rates in the simulation means a low, intermediate, or high value relative to the effective carrying capacity of the patch. Five days in the experiment is equivalent to approximately 5 days or 240 timesteps in the simulation (see methods for details on how time steps in simulations compare to days in experiment). (C) Histograms from the simulations showing the minimum generations required for the cip^R to reach a frequency of at least 50% in a metapopulation under each combination of network type and migration rate. Each data point represents the mean proportion of all of the replicate metapopulations on that day, and error bars represent standard error (SE).