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. 2023 Dec 1;12:101. doi: 10.1186/s40164-023-00458-3

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© The Author(s) 2023, Corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — A The study design describes 3 phases of our study: discovery, validation and further validation. B Bile samples within the patient cohorts specified by disease type (CCA, cholangiocarcinoma; AC, ampullary carcinoma; PDAC, pancreatic ductal adenocarcinoma; IPMC, PDAC originating from intraductal papillary mucinous neoplasm; CP, chronic pancreatitis). C Bile samples were collected from laparoscopic cholecystectomy and open pancreatoduodenectomy (PD) for microRNA profiling. D Venn diagrams describing differentially expressed microRNAs (miRNAs) in the discovery cohort, when comparing BPD to MPD