Table 3.

Treatment-related toxicities of proton and carbon-ion radiotherapy combined with chemotherapy

Characteristics	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Acute
Pulmonary
Cough	4 (20%)	1 (5%)	0	0	0
Pneumonitis	1 (5%)	3 (15%)	0	0	0
Gastrointestinal
Esophagitis	12 (60%)	6 (30%)	0	0	0
General
Weight loss	3 (15%)	0	0	0	0
Dermatitis	9 (45%)	1 (5%)	0	0	0
Hematologic
Leucopenia	3 (15%)	2 (10%)	5 (25%)	3 (15%)	0
Neutropenia	1 (5%)	6 (30%)	0	6 (30%)	0
Anemia	14 (70%)	5 (25%)	0	0	0
Thrombocytopenia	4 (20%)	0	0	0	0
Late
Pulmonary	10 (50%)	1 (5%)	0	0	0
Tracheal	0	0	1 (5%)	0	0
Esophageal	1 (5%)	3 (15%)	1 (5%)	0	0
Dermal	3 (15%)	0	0	0	0