Table 2.

Univariate and multivariate analysis of predictors selected by Cox regression model in the training set

Variables	Univariate analysis			Multivariate analysis
	HR (95% CI)	P Value		HR (95% CI)	P Value
Sex
Male	Reference			Reference
Female	0.839 (0.739–0.952)	0.006		0.851 (0.728–0.995)	0.043
Age
≤ 45	Reference			Reference
46–60	1.423 (1.122–1.805)	0.004		1.397 (1.100-1.774)	0.006
61–75	1.723 (1.361–2.182)	< 0.001		1.493 (1.175–1.896)	0.001
> 75	2.378 (1.768–3.198)	< 0.001		1.861 (1.376–2.516)	< 0.001
Region
Eastern	Reference			Reference
Southern	1.261 (1.011–1.572)	0.039		1.304 (1.045–1.628)	0.019
Western	0.685 (0.583–0.804)	< 0.001		0.726 (0.616–0.855)	< 0.001
Northern	0.909 (0.785–1.052)	0.199		0.926 (0.799–1.073)	0.306
Hospital
Specialized	Reference
General	1.032 (0.884–1.204)	0.693
Health insurance
Urban employees’ basic medical insurance	Reference
Urban residents’ basic medical insurance	0.986 (0.810–1.200)	0.885
New rural cooperative medical scheme	0.972 (0.853–1.108)	0.673
Self-pay	1.069 (0.794–1.440)	0.660
Other	0.687 (0.409–1.154)	0.156
Smoke
No	Reference			Reference
Yes	1.159 (1.034–1.298)	0.011		1.025 (0.89–1.182)	0.729
Alcohol use
No	Reference
Yes	1.074 (0.955–1.208)	0.231
TNM Stage
I	Reference			Reference
II	1.152 (0.830–1.597)	0.398		1.116 (0.797–1.561)	0.523
III	1.468 (1.108–1.944)	0.007		1.471 (1.094–1.978)	0.011
IV	2.142 (1.620–2.832)	< 0.001		1.977 (1.469–2.66)	< 0.001
Surgery
No	Reference			Reference
Yes	0.563 (0.439–0.721)	< 0.001		0.675 (0.519–0.879)	0.003
Chemotherapy
No	Reference			Reference
Yes	0.674 (0.589–0.770)	< 0.001		0.707 (0.616–0.813)	< 0.001
Radiotherapy
No	Reference			Reference
Yes	0.775 (0.681–0.882)	< 0.001		0.803 (0.702–0.917)	< 0.001

Notes: HR, hazard ratio; Eastern, Southern, Western, and Northern represent respectively Eastern of Shandong, Southern of Shandong, Western of Shandong, and Northern of Shandong; Specialized, General represent respectively specialized tumor hospitals and general hospitals