Table 2.

The basic information and HWE about the selected SNPs of CYP4B1

SNP ID	Chr: position	Alleles	Function	MAF		HWE (p value)	Haploreg4.1	RegulomeDB
				Cases	Controls
rs2297813	1:46799052	G/T	5’-UTR	0.142	0.133	0.469	Promoter histone marks; Enhancer histone marks; DNAse; Motifs changed; Selected eQTL hits	eQTL/caQTL + TF binding + any motif + Footprint + chromatin accessibility peak
rs12142787	1:46800918	G/A	intronic	0.255	0.234	0.295	Promoter histone marks; Enhancer histone marks; Motifs changed; GRASP QTL hits Selected eQTL hits	eQTL/caQTL + TF binding + any motif + Footprint + chromatin accessibility peak
rs3766197	1:46816155	C/T	intronic	0.167	0.166	0.762	Proteins bound; Motifs changed; GRASP QTL hits; Selected eQTL hits	eQTL/caQTL + TF binding / chromatin accessibility peak

p < 0.05;

SNP: Single nucleotide polymorphism; Chr: Chromosome; MAF: Minor allele frequency; HWE: Hardy-Weinberg.

HaploReg v4.1 (https://pubs.broadinstitute.org/mammals/haploreg/haploreg.php), RegulomeDB (https://regulome.stanford.edu/regulome-search/)