Table 3.
Analysis of the association between susceptibility of BC and CYP4B1 SNPs (Overall analysis)
| SNP ID | Model | Genotype | Case | Control | Adjusted by age, smoke and drink | |
|---|---|---|---|---|---|---|
| OR (95% CI) | p | |||||
| rs2297813 | Allele | G | 980 (85.8%) | 992 (86.7%) | 1.00 | 0.530 |
| T | 162 (14.2%) | 152 (13.3%) | 1.08 (0.85–1.37) | |||
| Codominant | G/G | 418 (73.2%) | 432 (75.5%) | 1.00 | 0.430 | |
| G/T | 144 (25.2%) | 128 (22.4%) | 1.17 (0.89–1.54) | |||
| T/T | 9 (1.6%) | 12 (2.1%) | 0.77 (0.32–1.86) | |||
| Dominant | G/G | 418 (73.2%) | 432 (75.5%) | 1.00 | 0.360 | |
| G/T-T/T | 153 (26.8%) | 140 (24.5%) | 1.13 (0.87–1.48) | |||
| Recessive | G/G-G/T | 562 (98.4%) | 560 (97.9%) | 1.00 | 0.510 | |
| T/T | 9 (1.6%) | 12 (2.1%) | 0.74 (0.31–1.78) | |||
| Over-dominant | G/G-T/T | 427 (74.8%) | 444 (77.6%) | 1.00 | 0.250 | |
| G/T | 144 (25.2%) | 128 (22.4%) | 1.17 (0.89–1.54) | |||
| Log-additive | 1.08 (0.85–1.37) | 0.520 | ||||
| rs12142787 | Allele | G | 846 (74.5%) | 874 (76.5%) | 1.00 | 0.250 |
| A | 290 (25.5%) | 268 (23.5%) | 1.12 (0.92–1.35) | |||
| Codominant | G/G | 316 (55.6%) | 339 (59.4%) | 1.00 | 0.410 | |
| A/G | 214 (37.7%) | 196 (34.3%) | 1.18 (0.92–1.51) | |||
| A/A | 38 (6.7%) | 36 (6.3%) | 1.14 (0.70–1.85) | |||
| Dominant | G/G | 316 (55.6%) | 339 (59.4%) | 1.00 | 0.190 | |
| A/G-A/A | 252 (44.4%) | 232 (40.6%) | 1.17 (0.93–1.48) | |||
| Recessive | G/G-A/G | 530 (93.3%) | 535 (93.7%) | 1.00 | 0.780 | |
| A/A | 38 (6.7%) | 36 (6.3%) | 1.07 (0.67–1.72) | |||
| Over-dominant | G/G-A/A | 354 (62.3%) | 375 (65.7%) | 1.00 | 0.220 | |
| A/G | 214 (37.7%) | 196 (34.3%) | 1.16 (0.91–1.48) | |||
| Log-additive | 1.12 (0.93–1.35) | 0.240 | ||||
| rs3766197 | Allele | C | 951 (83.3%) | 951 (83.4%) | 1.00 | 0.930 |
| T | 191 (16.7%) | 189 (16.6%) | 1.01 (0.81–1.26) | |||
| Codominant | C/C | 399 (69.9%) | 395 (69.3%) | 1.00 | 0.580 | |
| T/C | 153 (26.8%) | 161 (28.2%) | 0.94 (0.72–1.22) | |||
| T/T | 19 (3.3%) | 14 (2.5%) | 1.38 (0.68–2.79) | |||
| Dominant | C/C | 399 (69.9%) | 395 (69.3%) | 1.00 | 0.840 | |
| T/C-T/T | 172 (30.1%) | 175 (30.7%) | 0.98 (0.76–1.26) | |||
| Recessive | C/C-T/C | 552 (96.7%) | 556 (97.5%) | 1.00 | 0.340 | |
| T/T | 19 (3.3%) | 14 (2.5%) | 1.40 (0.69–2.83) | |||
| Over-dominant | C/C-T/T | 418 (73.2%) | 409 (71.8%) | 1.00 | 0.580 | |
| T/C | 153 (26.8%) | 161 (28.2%) | 0.93 (0.72–1.21) | |||
| Log-additive | 1.01 (0.81–1.26) | 0.900 | ||||
95% CI: 95% confidence interval; OR: Odds ratio