FIGURE 6.
Human organoids for vaccine development and drug discovery of SARS‐CoV‐2. (A) Generation of human tonsil organoids for SARS‐CoV‐2 infection and vaccine development. Reproduced with permission. 126 Copyright 2021, Springer Nature. (B) SOF (sofosbuvir) could inhibit SARS‐CoV‐2 replication in brain cells and rescue neurological impairments in human brain organoids. Reproduced with permission. 133 Copyright 2022, Public Library of Science. (C,D) QNHC (quinacrine dihydrochloride), imatinib, and MPA (mycophenolic acid) blocked the entry of SARS‐CoV‐2 in both hPSC‐derived lung organoids (C) and colonic organoids (D). Reproduced with permission. 40 Copyright 2021, Springer Nature. (E,F) EK1 and remdesivir inhibited infection of human intestinal organoids with SARS‐CoV‐2. Reproduced with permission. 88 Copyright 2021, Elsevier.