Skip to main content
. 2023 Nov 28;18:7065–7077. doi: 10.2147/IJN.S438229

Figure 2.

Figure 2

Genetic ablation of pericytes led to reduced bone mass (A) Schematic of NG2-tk mice modeling. Six-week-old female NG2-tk mice were intraperitoneally injected with GCV (50 mg/kg) once a day for 30 consecutive days in order to delete NG2+ pericytes. (B) Representative micro-CT images displaying the three-dimensional architectures of femurs from WT mice and NG2-tk mice (after GCV treatment). Scale bar, 1mm (left panels); 500 μm (right panels). (C) Micro-CT analysis of BV/TV, SMI, Tb.Th, and Tb.N in femurs of WT mice and NG2-tk mice (after GCV treatment, n = 6). (D) Representative H&E staining images of femurs from WT mice and NG2-tk mice (after GCV treatment). Scale bar, 500 μm. (E) Quantification of bone volume fraction (BV/TV) in femurs from WT mice and NG2-tk mice (after GCV treatment, n = 6). Data are presented as mean ± S.E.M. P-values < 0.05 were considered statistically significant, as follows: *P < 0.05; ***P < 0.001; ****P < 0.0001.