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. 2023 Nov 28;18:7065–7077. doi: 10.2147/IJN.S438229

Figure 3.

Figure 3

Genetic ablation of pericytes activated bone resorption (A) Representative immunostaining images of femurs from WT mice and NG2-tk mice (after GCV treatment). NG2+ (red) pericytes, endomucin+ (green) endothelial cell, and nuclear (blue) DAPI staining. Scale bar, 50 μm. (B) Quantification of NG2+ pericyte number in subepiphyseal zone of femurs from WT mice and NG2-tk mice (after GCV treatment, n = 6). (C) Representative TRAP staining images of mouse femurs from WT mice and NG2-tk mice (after GCV treatment). Scale bar, 500 μm (upper panels); 100 μm (lower panels). (D) Quantification of osteoclast surface per bone surface (Oc.S/BS) and osteoclast number per bone perimeter (Oc.N/B.Pm) in subepiphyseal zone of femurs from WT mice and NG2-tk mice (after GCV treatment, n = 6). Data are presented as mean ± S.E.M. P-levels < 0.05 were considered statistically significant, as follows: **P < 0.01; ****P < 0.0001.