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. 2023 Nov 28;16:5613–5628. doi: 10.2147/JIR.S419186

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© 2023 Lou et al.

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Knockdown of ATF3 alleviates symptoms and pathological knee joint damage in rats with OA. (A) Width of the knee joints of rats. (B) Knee pain was assessed by weight-bearing test; (C–E) Serum levels of TNF-α (C), IL-8 (D) and IL-6 (E) were measured by ELISA (n = 4); (F) Histopathological changes of the knee joint from rats (n = 2) were observed by safranin O staining. Scale bar = 100 μm. Error bars are mean ± s.d. *P < 0.05 and **P < 0.01 vs OA+si-NC group.