| Causes |
Description |
| Increased intake |
Amplified absorption due to poor gut motility (typical in the elderly, treatment with anticholinergics or opioids, inflammatory bowel disease patients). |
| Laxatives (Mg2+ citrate), antacids (Mg2+ trisilicate), bowel preparation agents (Na+ picosulfate/Mg2+ citrate), and in treatment for eclampsia (intravenous Mg2+ sulfate). |
| Extreme oral intake in chronic kidney disease patients. |
| Milk-alkali syndrome (large amounts of Ca2+ and Mg2+). |
| Newborns to mothers receiving Mg2+ sulfate for eclampsia. |
| Decreased renal excretion |
Acute or chronic kidney disease. |
| Adrenocortical insufficiency |
| Hyperparathyroidism |
| Hypercalcemia and/or hypocalciuria e.g., Familial hypocalciuric hypercalcemia (FHH). |
| Lithium-based psychotropic drugs. |
| Compartment shift or leak |
Hemolysis. |
| Tumor lysis syndrome. |
| Rhabdomyolysis. |
| Acidosis, such as in diabetic ketoacidosis. |