Table 2.
Structures of TCR-mimic (TCRm) antibodies bound to cancer neoantigen pMHC ligands.
| TCRm–pMHC complex | PDB code (reference) | Neoepitope | Affinity wild-type |
Affinity mutant |
Basis for neoepitope specificity |
|---|---|---|---|---|---|
| H2–p53R175H–HLA-A*02:01 | 6W51 (61) | HMTEVVRHC | UD | 86 nM | Direct antibody contacts with mutation |
| V2–KRASG12V–HLA-A*03:01 | 7STF (63) | VVVGAVGVGK | UD | 24 nM | Direct antibody contacts with mutation, peptide induced fit |
| 2Q1–IDH2R140Q–HLA-B*07:02 | 6UJ9 (64) | SPNGTIQNIL | 846 nM | 44 nM | Limited direct antibody contact with mutation, engagement of mutant peptide backbone conformation |
UD, undetectable.