Table 2.

Decreased proteins in macrophages infected with Paracoccidioides brasiliensis yeast cells involved in energy production.

Accession number1	Protein description and biological process2	Score3	Fold change4
	Tricarboxylic-acid cycle
P53396	ATP-citrate synthase	1520.56	*
O75390	Citrate synthase_ mitochondrial	12200.29	*
A2A274	Aconitate hydratase_ mitochondrial	916.17	*
P50213	Isocitrate dehydrogenase [NAD] subunit alpha_ mitochondrial	1918.82	*
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	975.87	*
P09622	Dihydrolipoyl dehydrogenase_ mitochondrial	1686.78	*
P53597	Succinate–CoA ligase [ADP/GDP-forming] subunit alpha_ mitochondrial	651.86	*
A0A5K1VW95	Malate dehydrogenase	15614.68	*
C9JRL4	Cytosolic malate dehydrogenase (Fragment)	13862.17	*
P07954	Fumarate hydratase_ mitochondrial	2669.02	*
	Oxidative phosphorylation
P13804	Electron transfer flavoprotein subunit alpha_ mitochondrial	1834.68	*
C9J8T6	Cytochrome c oxidase copper chaperone	7210.97	*
Q5SQT6	Inorganic diphosphatase	403.07	*
H0Y9D8	Inorganic diphosphatase (Fragment)	1522.39	*
Q15181	Inorganic pyrophosphatase	721.87	*
Q9H2U2	Inorganic pyrophosphatase 2_ mitochondrial	1668.87	*
K7EJP1	ATP synthase subunit alpha_ mitochondrial (Fragment)	17166.89	*
P06576	ATP synthase subunit beta_ mitochondrial	18491.35	*
P36542	ATP synthase subunit gamma_ mitochondrial	1169.11	*
A8MUH2	ATP synthase-coupling factor 6_ mitochondrial	1566.69	*
Q93050	V-type proton ATPase 116 kDa subunit a1	2050.49	*
O75323	Protein NipSnap homolog 2	2351.76	*

¹ Accession number of matched protein from Homo sapiens’ macrophages Uniprot database (https://www.uniprot.org/).

² Proteins annotation from Homo sapiens’ database or by homology in NCBI database (http://www.ncbi.nlm.nih.gov/) and biological process according to the classification of KEGG (https://www.genome.jp/kegg/), UniProt database (https://www.uniprot.org/), NCBI database (http://www.ncbi.nlm.nih.gov/) and CORUM database (http://mips.helmholtz-muenchen.de/corum/).

³ PLGS score is the result of different mathematical models for peptide and fragment assign prediction.

⁴ Fold-change values were obtained by dividing the values of protein abundance (in fmol) from macrophages during infection by live PB by the abundance in the uninfected macrophages. Proteins with a minimum fold-change of 50% (≤ 0.67) were considered to be dowregulated.

^* Proteins detected only in uninfected macrophages.

A fold equal to or less than 0.67 was considered.